Cd47 and exportin 1

Author: qtjy

August undefined, 2024

WebBackground: CD47 is a widely expressed cellular receptor well known for its immunoregulatory functions. By interacting with its ligands, including thrombospondin-1 …

Frontiers A Novel Blockade CD47 Antibody With Therapeutic Potential ...

WebJan 5, 2024 · Macrophages as components of the innate immune system play a critical role in antitumor responses. Strategies for targeting CD47 are becoming a hot spot for cancer therapy. The expression of CD47 is exercised by macrophages to make a distinction between “self” or “nonself.” Anti-CD47 antibodies block the interaction between … WebNov 1, 2024 · CD47 interactions with exportin-1 limit the targeting of mG-modified RNAs to extracellular vesicles. Authors: Sukhbir Kaur Alejandra Cavazos Saldana Abdel G Elkahloun Jennifer D Petersen Anush Arakelyan Satya P Singh Lisa M Jenkins Bethany Kuo Bianca Reginauld David G Jordan Andy D Tran Weiwei Wu Joshua Zimmerberg Leonid Margolis … flats for sale litherland

Role of CD47 in Hematological Malignancies Journal of …

WebJul 16, 2024 · CD47, or integrin-associated protein, is a cell surface ligand expressed in low levels by nearly all cells of the body. It plays an integral role in various immune responses as well as autoimmunity, by sending a potent “don’t eat me” signal to prevent phagocytosis. A growing body of evidence demonstrates that CD47 is overexpressed in various … WebNational Center for Biotechnology Information WebOct 30, 2024 · Many therapeutic products targeting CD47 are being developed, including anti-CD47 mAbs, bi-specific antibodies (BsAbs) to CD47 and other molecules, as well as … flats for sale lingfield court harborne

Frontiers Construction of Exosomes that Overexpress CD47 and ...

Potential New Cancer Immunotherapy: Anti-CD47-SIRPα Antibodies

WebJun 13, 2024 · CD47 performs a vital function in cancer therapy by binding to different SIRPα, thrombospondin 1, and integrin. However, its role in tumor immunity and its … WebJun 13, 2024 · CD47 is a highly glycated protein distributed on the surface membrane of several cells, including red blood cells and non-hematopoietic cells, but its expression levels varied by cell types 2, 4,... flats for sale letchworthWebMar 18, 2024 · Specific interactions of CD47 and its cytoplasmic adapter ubiquilin-1 with components of the exportin-1/Ran nuclear export complex were identified and confirmed by coimmunoprecipitation. Exportin-1 is known to regulate nuclear to cytoplasmic trafficking of 5’-7-methylguanosine (m7G)-modified microRNAs and mRNAs that interact with its cargo ... flats for sale leith

"WebMethods: To improve the antibody selectivity and therapeutic window, we developed a novel affinity-tuned bispecific antibody targeting CD47 and programmed death-ligand 1 (PD-L1) to antagonize both innate and adaptive immune checkpoint pathways. This PD-L1-targeted CD47 bispecific antibody was designed with potent affinity for PD-L1 and moderate ... " - Cd47 and exportin 1

Cd47 and exportin 1

Frontiers CD47 as a promising therapeutic target in oncology

WebCD47 signaling limits the trafficking of m7G-modified RNAs to EVs through physical interactions with the exportin-1/Ran transport complex, perturbing nuclear to cytoplasmic transport. CD47 is a marker of self and a signaling receptor for thrombospondin-1 that is also a component of extracellular vesicles (EVs) released by various cell types. WebNCBI Full Gene Name CD47 molecule NCBI Gene Aliases IAP, MER6, OA3 Clonality Monoclonal Validation KD/KO Validated Specifications/Features 20ul available Proteintech Group Inc 2201 W. Campbell Park Drive Chicago, Illinois 60612 United States Phone: 1-888-4PTGLAB 1-312-455-8408 Company Profile Website: http://www.ptglab.com …

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WebMar 14, 2024 · First, we determined expression of CD47 and CD274 in mouse cancer cells. As shown in Fig. 1A, mouse cancer cells −4T1, LCC, B16F10 and CT26- had CD47 + cells with high expression rates of... WebNov 10, 2024 · Exportin 1 (XPO1), also known as chromosome region maintenance protein 1, plays a crucial role in maintaining cellular homeostasis via the regulated export of a range of cargoes, including...

WebThe functional role of TSP-1/CD47 signaling axis in psoriasis was assessed in Th17 and Treg differentiation assays. Additionally, small interfering RNA assays specific to TSP-1 were performed in CD4+ T cells and monocyte derived DC to specifically evaluate the function of this protein. Lesional skin of psoriasis patients expressed lower TSP-1 ... WebInteraction with CD47 was inhibited following alkylation of exportin-1 at Cys 528 by its covalent inhibitor leptomycin B. Leptomycin B increased levels of m 7 G-modified RNAs, and their association with exportin-1 in EVs released from wild type but not CD47-deficient …

WebJul 16, 2024 · Role of CD47 in hematological neoplasms. The following section will address the role of CD47 in hematological malignancies. The ubiquitous high level of CD47 gene … WebA recent report demonstrated that CD47 blockade also promotes T-cell–mediated elimination of immunogenic tumors and HIF-1 is known to inhibit effector T cells through …

WebMar 21, 2024 · CD47 (CD47 Molecule) is a Protein Coding gene. Diseases associated with CD47 include Hereditary Spherocytosis and Glanzmann Thrombasthenia 1 . Among its …

WebSep 22, 2024 · This study is the first to elaborate CD47-SIRPα macrophage-mediated immunotherapy of tumors. Scholars have clarified the mechanism of action of CD47-SIRPα, and macrophage-mediated tumor immunotherapy has gained increasing attention. CD47 may play an inhibitory role in NK cell-mediated cytotoxicity against cancer cells, … flats for sale linlithgow high streetWebThe transmembrane protein, CD47, is recognized as an important innate immune checkpoint, and CD47-targeted drugs have been in development with the aim of inhibiting the interaction between CD47 and the regulatory glycoprotein SIRPα, for antitumor immunotherapy. flats for sale lincolnshire coastWebFeb 2, 2024 · This screen nominated exportin-1, encoded by XPO1, as a therapeutic target. XPO1 was highly and ubiquitously expressed in SCLC relative to other lung cancer histologies and other tumor types. XPO1 knockout enhanced chemosensitivity, and exportin-1 inhibition demonstrated synergy with both first- and second-line … flats for sale livingston west lothianWebJan 28, 2024 · Characterization of CD47 Structure and Ligands. CD47 is a transmembrane protein that is glycosylated on the surface of a variety of different cell types (13, 14).Lindberg et al. isolated and purified CD47, which is also known as integrin-associated protein (IAP) ().CD47 belongs to the immunoglobulin superfamily and is a supramolecular complex … flats for sale kings cross londonWebCD47: role in the immune system and application to cancer therapy Cell Oncol (Dordr). 2024 Feb;43 (1):19-30. doi: 10.1007/s13402-019-00469-5. Epub 2024 Aug 14. Authors Seyed Mohammad Gheibi Hayat 1 , Vanessa Bianconi 2 , Matteo Pirro 2 , Mahmoud R Jaafari 3 4 , Mahdi Hatamipour 3 , Amirhossein Sahebkar 5 6 7 8 Affiliations check the qualityWebIntriguingly, Kaur et al. found that CD47 indirectly interacts with exportin-1 via ubiquilin-1, its known cytoplasmic binding partner, and limits the intracellular trafficking of … flats for sale lochgellyWebCD47 interacts with several membrane integrins and also acts a receptor for thrombospondin (THBS1). It is involved in a range of cellular processes, including apoptosis, proliferation, adhesion, and migration. CD47 also … flats for sale london w1