Clofarabine triphosphate

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August undefined, 2024

WebAug 2, 2024 · Clofarabine side effects. Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin … WebOct 16, 2004 · Clofarabine has proven to be effective in the treatment of adult and pediatric acute myelogenous leukemia (AML). To investigate if clofarabine could be used with …

Clofarabine Nature Reviews Drug Discovery

WebAug 1, 2014 · Clofarabine triphosphate is an intracellular active metabolite of clofarabine. In the present study, we developed and validated a rapid, sensitive, and selective liquid chromatography–tandem ... WebAug 1, 2014 · Clofarabine triphosphate is an intracellular active metabolite of clofarabine. In the present study, we developed and validated a rapid, sensitive, and selective liquid … book of blood streaming ita

Clofarabine triphosphate C10H14ClFN5O12P3 - PubChem

WebThe overall response rate for patients treated with a single-agent trial of clofarabine was 38% vs 100% in rational combinations of clofarabine with cyclophosphamide and etoposide . 7 From a molecular point of view, clofarabine, fludarabine (in FLAG) and cladribine (in CLAG regimens) are all purine nucleoside analogues which possess similar ... WebDec 1, 2009 · However, clofarabine triphosphate is not a potent inhibitor of DNA polymerase-β, mitochondrial DNA polymerase-γ, or DNA primase [24]. In a recent article Chen et al. suggested that clofarabine action may as well involve an RNA-directed mechanism. Clofarabine triphosphates were shown to cause chain termination in the … WebClofarabine is a deoxyadenosine analog synthesized with the intention of retaining the favorable mechanistic properties of fludarabine and cladribine while eliminating their undesirable characteristics. book of boba credit scene

Clofarabine: Structure, Mechanism of Action, and Clinical

WebJan 31, 2024 · The dose-response curves showed that sensitivity of the ES cells to clofarabine and clofarabine-5′-triphosphate were highly similar with IC 50 concentrations of 0.15 and 0.17 µmol/L in TC-71 ... WebFinally, clofarabine triphosphate directly induces programmed cell death by causing the release of numerous apoptotic compounds . The pharmacologic effects and activation of clofarabine are predominantly dependent on dCK phosphorylation. dCK is a key enzyme in the deoxyribonucleoside salvage pathway. It phosphorylates free nucleosides such as ... god\\u0027s encouraging wordsWebOct 1, 2006 · Secondly, clofarabine triphosphate is a potent inhibitor of ribonucleotide reductase (IC 50 = 65 nM), presumably by binding to the allosteric site on the regulatory … book of blue magic pdf

"WebPhosphorylated to form clofarabine triphosphate, which competes with dATP for DNA polymerase-alpha and -epsilon and potently inhibits ribonucleotide reductase (IC50 = 65 nM). Induces apoptosis by directly altering mitochondrial transmembrane potential. Demonstrates growth inhibition and cytotoxic activity in a variety of leukemias and solid … " - Clofarabine triphosphate

Clofarabine triphosphate

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WebMay 1, 2005 · Clofarabine is converted intracellularly by deoxycytidine kinase to the 5′-monophosphate metabolite, and then by mono- and diphosphokinases to the active 5′-triphosphate form. Clofarabine ... WebThe population pharmacokinetics of plasma clofarabine and intracellular clofarabine triphosphate were characterized in pediatric patients with acute leukemias. Traditional model-building techniques with NONMEM were used.

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WebClofarabine is metabolized intracellularly to the active 5'-monophosphate metabolite by deoxycytidine kinase and 5'-triphosphate metabolite by mono- and di-phospho-kinases. … WebFeb 1, 2005 · As clofarabine is a potent inhibitor of ribonucleotide reductase (RnR), we hypothesized that clofarabine will modulate ara-c triphosphate accumulation and increase the antileukemic activity of cytarabine (ara-C).

WebJun 6, 2011 · Clofarabine (ClF), an adenosine analog, is used in the treatment of refractory leukemias. Its mode of cytotoxicity is thought to be associated in part with the … WebNCATS Inxight Drugs — Clofarabine triphosphate ... Chemical

WebClofarabine is used to treat acute lymphoblastic leukemia (ALL; a type of cancer of the white blood cells) in children and young adults 1 to 21 years old who have already … WebAug 1, 2014 · Clofarabine triphosphate is an intracellular active metabolite of clofarabine. In the present study, we developed and validated a rapid, sensitive, and selective liquid chromatography–tandem mass spectrometry method (LC–MS/MS) for quantifying clofarabine triphosphate concentrations in human peripheral blood mononuclear cells …

WebApr 19, 2024 · The actions of clofarabine triphosphate on ribonucleotide reductase and incorporation in the DNA repair patch suggest that a mechanism-based combination with arabinosylcytosine and DNA-damaging...

WebClinical diagnosis of hepatocellular carcinoma (HCC) relies heavily on radiological imaging. However, information pertaining to liver cancer treatment such as the proliferation status is lacking. Imaging tumor proliferation can be valuable in patient management. This study investigated 18F-labeled clofarabine ([18F]CFA) targeting deoxycytidine kinase (dCK) … god\u0027s empowermentWebJul 15, 2024 · Collect and arrange disposal. Keep the chemical in suitable and closed containers for disposal. Remove all sources of ignition. Use spark-proof tools and explosion-proof equipment. Adhered or collected material should be promptly disposed of, in accordance with appropriate laws and regulations. book of boba budgetWebMay 15, 2024 · In this context, we developed and validated a liquid chromatography tandem mass spectrometry (LC-MS/MS) method to study the formation of 5'-triphosphorylated … god\u0027s enduring love scriptureWebMay 1, 2005 · Clofarabine is converted intracellularly by deoxycytidine kinase to the 5′-monophosphate metabolite, and then by mono- and diphosphokinases to the active 5′-triphosphate form. book of boba end credit sceneWebApr 19, 2024 · Clofarabine triphosphate was found to be a potent inhibitor of the incorporation of dATP by DNA polymerase α, with a K i value of approximately 1 μM (K … god\\u0027s equalityWebApr 19, 2024 · Clofarabine triphosphate was found to be a potent inhibitor of the incorporation of dATP by DNA polymerase α, with a K i value of approximately 1 μM (K m for dATP was 4 μM), but it was a weak inhibitor of DNA polymerase β (involved in DNA repair) and γ (involved in mitochondrial DNA synthesis). god\u0027s encouragement for womenWebUse in Cancer. Clofarabine is approved to treat: Acute lymphoblastic leukemia that has recurred (come back) or is refractory (does not respond to treatment) in children and … book of boba ep 6