Simon's minimax two-stage design

WebbObjective To compare Gehan two-stage design and Simon two-stage design in sample size calculations for phase Ⅱ clinical trials of anti-tumor drugs. Methods We explained the sample size calculation methods with a single-stage design, Gehan two-stage design, and Simon optimal two-stage and minimax two-stage designs in line with the principle of … Webb20 nov. 2024 · 单臂试验Simon两阶段设计就是能很好的决定早期无效终止的一种方法。 两阶段设计，顾名思义就是把试验分成两个阶段，首先纳入较少的样本进入试验的第一阶 …

Optimal, minimax and admissible two-stage design for …

WebbTHE DESIGN • Two stages (the design could have more than two stages, but less practical and not used) • Enroll n. 1 . patients in stage 1; the trial is . stopped. if r. 1 . or fewer … Webb1 juli 2024 · Compared with the Gehan two-stage design, the Simon two-stage design has the advantage of being able to determine an early termination of trials when no or low … greek coffee reading symbols https://envisage1.com

肿瘤新药Ⅱ期临床试验常用二阶段设计的样本含量估计及其 SAS实现

WebbCI_UL: (1-2*alpha) CI upper limit. EN.p0: expected sample size under H0. PET.p0: probability of terminating the trial at the end of the first stage under H0. MIN: column … Webb8 juni 2024 · Simon’s two-stage design (Simon, 1989) is still one of the most often used designs in oncology phase 2 trials in single-arm trials testing a binary endpoint. After n1 patients (stage 1) the trial is … Webb20 maj 2024 · 结果在Simon 和Fleming 的两阶段设计中，容许设计的最大样本量小于最优设计但大于极小极大设计。同时，容许设计的期望样本量小于极小极大设计，但大于最优 … greek coin beard crest helmet

Optimal two-stage designs for exploratory basket trials

Category:[Sample Size Calculation using SAS for PhaseⅡin Two-stage …

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Simon's minimax two-stage design

Simon’s minimax and optimal and Jung’s admissible two-stage …

Webb20 maj 2024 · As listed in Table 3, sample size is estimated for optimal, admissible and minimax design based on Simon’s and Fleming’s two-stage design. In Simon’s design, … Webb2 u (1 p( x 1 d r 1))--- (3) Minimax Design 的目標是希望總樣本數為最小，總樣本數即為以下式(4)，故 限制式(1)、(2)再加上使得式(4)為最小的條件來求解。在此設計下所得到的總 …

Simon's minimax two-stage design

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WebbAbstract. This article describes a new Stata command called simontwostage, which calculates the critical values and sample sizes for two-stage designs for phase II … WebbSimon两阶段设计常用于肿瘤药物单臂两阶段试验，具有节省样本量，早期发现试验无效及时终止试验，避免受试者接受无效治疗，节省时间和成本，更加符合伦理要求的特点。 …

Webb15 apr. 2016 · Simon's optimal two‐stage design has been widely used in early phase clinical trials for Oncology and AIDS studies with binary endpoints. With this approach, the second‐stage sample size is fixed when the trial passes … Webb15 dec. 1997 · This work proposes single-stage and two-stage designs for randomized phase II clinical trials, and develops a program to compute various type I error rates and powers exactly to achieve this objective. 6 A new adaptive design based on Simon's two-stage optimal design for phase II clinical trials. Hua Jin, Zhen Wei Mathematics

Webbpractically synonymous with the Simon’s optimal and MINIMAX two stage (1989) –designs which have stood the test of time with their pracmatic trade-off between the need to stop a trial early for inefficacy if response rates were low and the likely overshoot of interim analysis in small trials.” Roger A’Hern (2014) Webb1 nov. 2010 · Table 2 displays the minimax and optimal designs under H 0 and H 1 with and without efficacy stopping for p 0 = 0.1 and p 1 = 0.3. The minimax designs now …

WebbOptimal Two-Stage Designs For Phase II Clinical Trials. Richard Simon, Controlled Clinical Trials 10:1-10, 1989. Enter probability of accepting poor drug (alpha) [between 0 and 0.3 …

Webb15 apr. 2024 · 2 Department of Biostatistics, MD Anderson Cancer Center, Houston, TX 77030. ... Optimal Minimax. Calculate. Design Summary; Protocol Template; Reference; … flow activewear ancasterWebbof the type 1 and type 2 errors. Two-stage designs which minimize the maximum sample size are also determined. Optimum and "minimax" designs for a range of design … flow action types in pegaWebbSimon's 2-stage Phase II design Description Calculates Optimal and Minimax 2-stage Phase II designs given by Richard Simon Usage ph2simon (pu, pa, ep1, ep2, nmax=100) … greek coins auctionsWebb1 juli 2024 · The trial uses a Simon's minimax two-stage design. We hypothesized that excluding a CBR ≤5% while targeting an improvement of the CBR to ≥20% would be an … flowactivo musicaWebb27 mars 2024 · Optimal two-stage designs for phase II clinical trials - PubMed. The primary objective of a phase II clinical trial of a new drug or regimen is to determine whether it … greek coil potteryWebbDescription Calculates Optimal and Minimax 2-stage Phase II designs given by Richard Simon Usage ph2simon (pu, pa, ep1, ep2, nmax=100) # S3 method for ph2simon print (x, … flow activity suspendedWebbSimonのMinimax法 薬剤が無効な場合に早期中止を判断するための2段階デザイン 無効な場合の患者数の最大値を最小にしたい． 手順はSimonの最適法と同様 ※Simon … flow activity examples