Although based on a small number of cases, the incidence of myopathy across a number of large trials increased when simvastatin 40 mg was administered with amlodipine. Similarly the incidence of muscle symptoms specifically associated with rises in creatine kinase (CK) with simvastatin 40 mg was between … Visa mer Simvastatin is metabolised through the CYP3A4 pathway. Concomitant use of CYP3A4 inhibitors has the potential to increase exposure to simvastatin[footnote … Visa mer The HPS trial demonstrated that simvastatin 40 mg has a clearly positive benefit-risk profile vs placebo , however, the additional benefit of simvastatin 40 mg versus … Visa mer Drug Safety Update August 2012, vol 6, issue 1: S1 BNF section 2.12: Lipid-regulating drugsArticle citation: Drug Safety Update October 2012, vol 6, issue 3: H1 Visa mer WebbThe MHRA . Drug Safety Update (August 2012) highlights changes to the simvastatin SmPC regarding interactions that can increase the risk of myopathy and/or rhabdomyolysis. When used with amlodipine, the maximum dose of simvastatin is now 20mg; higher doses are ‘off-label’. For . patients taking amlodipine and simvastatin …
Simvastatin: dose limitations with concomitant …
WebbSimvastatin is an HMG-CoA reductase inhibitor that is metabolized by the cytochrome P450 (CYP) 3A4. The calcium antagonist amlodipine is also metabolized by CYP3A4. … Webb60 interactions Acenocoumarol Miconazole greatly increases the anticoagulant effect of Acenocoumarol. MHRA advises avoid unless INR can be monitored closely; monitor for signs of bleeding. Severity: Severe Evidence: Study Alfentanil Miconazole is predicted to increase the exposure to Alfentanil. howards grove meat market
[Medication management: Simvastatin and Amlodipin - PubMed
Webb4 aug. 2024 · liver problems - nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes). Common Zocor side effects may include: headache; constipation, nausea, stomach pain; or. cold symptoms such as stuffy nose, sneezing, sore throat. WebbThe MHRA products website allows you to find: The leaflets which are provided with medicines; The description of the medicinal product’s properties and how it can be used; Scientific reports about marketing authorisations for medicines; You can look for any word, phrase or Product Licence number (PL) using the search tool. WebbThe study found that the patients on simvastatin achieved the target LDL level of less than 130, more than those on pravastatin (65 percent on simvastatin versus 35 percent on pravastatin). The most common side effects of the statins in general are nausea, gas, and upset stomach. howards grove school 365